• CAUTION: Gastro-intestinal ADRs (Risk factors: age>75, GI ulcer, antithrombotics, steroids, SSRIs, high alcohol use)
    • If NSAIDs are essential: Consider gastro-protection with a PPI in those with GI risk factors
  • CAUTION: Cardiovascular ADRs (Risk factors: CVD risk>20%, previous CVD events, heart failure)
  • CAUTION: Renal ADRs (Risk factors: age>65, on ACEI, ARBs and/or diuretics, CKD or heart failure
    • If NSAIDs are essential: Monitor eGFR; advise patient to stop during intercurrent illness